Everything you need to know about PDRN

Confused by the endless stream of skincare initials? Here’s why PDRN is the one acronym worth making room for in your beauty vocabulary.

A close up of a hand squeezing a pipette of oil onto the palm of another hand. Peach background. Fashion, editorial vibe.

If you’ve spent more than five minutes scrolling social media, you’ll know that skincare has become obsessed with initialisms. There’s AHA, BHA, PHA, HA, EGF, LED and enough letters to make you feel like you’ve wandered into a game of Scrabble. While SPF remains non negotiable, PDRN is the new four letter emerging as a popular supporting step for those looking to help their skin recover and maintain a healthy looking glow, no matter the season.

Anua PDRN Hyaluronic Acid Capsule 100 Serum 30ml, £20
Anua PDRN Hyaluronic Acid Capsule 100 Serum 30ml, £20

What is PDRN?

PDRN, short for polydeoxyribonucleotide, is the ingredient behind the so-called “salmon sperm facial” that has become one of the most talked-about treatments in aesthetic medicine. Before you recoil in horror, let’s clear something up. PDRN is made up of DNA fragments, traditionally derived from salmon, which researchers have been studying for decades because of their ability to support tissue repair and regeneration.

Biodance Caviar PDRN Real Deep Mask (4 Pack), £14.90
Biodance Caviar PDRN Real Deep Mask (4 Pack), £14.90

What are the benefits?

Research suggests it may help support wound healing, calm inflammation, encourage collagen production and improve the appearance of uneven pigmentation.

COSRX PDRN EXOSOME Skinplaning Glaze Mask 50ml, £22.99
COSRX PDRN EXOSOME Skinplaning Glaze Mask 50ml, £22.99

How to use PDRN in your skincare routine

For years, PDRN was mostly found in professional treatments carried out in clinics and medical spas. It’s often applied after procedures such as microneedling and laser treatments, when the skin is primed to absorb restorative ingredients more effectively.

More recently, PDRN has made its way into at-home skincare products, including serums, creams and sheet masks. While these won’t work as deeply as professional treatments, regular use may help improve skin texture, elasticity and glow over time.

Eqqual Berry Aloe PDRN Calming Toner 150ml, £19.99
Eqqual Berry Aloe PDRN Calming Toner 150ml, £19.99

Is PDRN worth it?

Like most skincare ingredients, it’s not a miracle cure and it won’t erase every sign of ageing overnight. But if your goals include brighter, calmer, healthier-looking skin, PDRN is certainly one of the more interesting ingredients to emerge in recent years. And in a beauty world overflowing with confusing acronyms, it’s one worth remembering.

Inkey Lab PDRN Serum, £18
Inkey Lab PDRN Serum, £18
Mario Badescu Advanced Peptide PDRN Jelly Cream 59ml, £20
Mario Badescu Advanced Peptide PDRN Jelly Cream 59ml, £20
Medik8 Exo-PDRN Prismatic+ Serum 30ml, £79
Medik8 Exo-PDRN Prismatic+ Serum 30ml, £79
Glow Recipe PDRN Repair + Soothe Toner Pads, £27
Glow Recipe PDRN Repair + Soothe Toner Pads, £27
No7 Good Intent Dew Bank Water Serum with PDRN, £19.95
No7 Good Intent Dew Bank Water Serum with PDRN, £19.95

Subscribe and stay updated. Join the Spell Squad

Sign up to receive exclusive news, alerts and competitions, delivered straight into your inbox every month.

Processing…
Success! You're on the list.

By signing up, you agree to our Privacy Policy and Terms.

Hot off the press

Follow Spell Magazine on Issuu and get access to all issues!

Stay on trend and never miss a copy again.

Spell Magazine Summer 2026 issue
Spell Magazine 14 Summer 26 – out now

Style decoded

Tried & tested extensions, and more!

Here at Spell Magazine, we live, love and breathe what we do.

To stay connected with our exclusive hair, beauty and lifestyle content, and have it delivered straight to your inbox, sign up to our newsletter today.

Newsletter

Sign up to receive exclusive news, alerts and competitions, delivered straight into your inbox every month.

Processing…
Success! You're on the list.

2025 © Spell Magazine

Begin typing your search above and press return to search. Press Esc to cancel.

Or, browse through the popular tags: